For our next webinar on 16 April we welcome another 2024 Congress Award winner. Dr Daigo Inoue was the worthy winner of the 2024 Basic Research Award in Iguazu Falls, Brazil.

Solar lentigo (SL) is one of the most conspicuous skin concerns in photoaging. It is caused by chronic UV exposure, which leads to hyperpigmentation. One of the biggest challenges of SL research is to obtain live skin tissues to understand dynamics of its cellular microenvironment. To overcome the problem, Dr Daigo Inoue’s team at Shiseido aimed to develop a non-invasive measurement technique for SL at the cellular level by revealing a key microenvironment of SL. Measurement of NAD(P)H fluorescent lifetime decay by fluorescence lifetime microscopy, FLIM, indicated that oxidative-phosphorylation (OXPHOS) activity of mitochondria was downregulated in SL. Excessive melanin-deposition caused OXPHOS downregulation and induced senescence phenotypes by arresting cell cycle and increasing SASPs. An active ingredient complex significantly improved OXPHOS downregulation in SL and prevented the senescence phenotypes induced by excessive melanin in vitro. The results suggest an excessive melanin-dependent senescence process and provide the pragmatic solution improving the deteriorated microenvironment of SL.

REGISTER HERE

TIMES
Wednesday 16 April
16h West Coast USA • 18h Mexico City, Chicago • 19h East Coast USA, Bogotá • 21h Sao Paolo • 0h London
Thursday 17 April
1h Central Europe, West Africa • 2h South Africa, Tel Aviv • 5h30 New Delhi • 8h Singapore, HK, China, Taipei • 9h Japan, Korea • 11h Melbourne • 13h Wellington

BIOGRAPHY
After receiving PhD (Developmental/Cell Biology) at Kyushu University in Japan, Dr Daigo Inoue began his career as a postdoc at European Molecular Biology Laboratory (EMBL) in Germany in 2009, investigating dynamics of embryonic development by using a Japanese killifish, medaka. As a recipient of the prestigious Human Frontier Science Program (HFSP) long-term fellowship for overseas research, he led his own projects for over eight years. In 2017 he joined Shiseido Co Ltd to explore new frontiers in dermatology, with a particular focus on the enigma of solar lentigo (dark spot) formation. Since then, he has been deeply engaged in studying the parallels between skin homeostasis and embryonic development, where the underlying molecular mechanisms of cellular dynamics play a crucial role, even within the age-spot-specific microenvironment.

In 2024 Dr Inoue was awarded the 2024 Basic Research Award for his work at the IFSCC Congress in Iguazu Falls, Brazil.