Dr. Emmanuel Coste, EXSYMOL

Cell longevity is impacted by exposome factors (ROS, AGEs, ALEs) and stress, which can damage DNA, leading cells to apoptosis or senescence. Senescent cells release SASP, affecting nearby cells. The immune system naturally clears senescent cells, but declines with age, causing accumulation and contributing to premature aging.

To prevent or treat senescence and enhance cell longevity, both preventive and curative solutions exist. Preventive measures reduce ROS and AGEs/ALEs, while curative approaches target SASP inhibition, restore immune function, and limit senescence spread.

Scutellaria baicalensis, rich in baicalein and wogonin, protects against oxidative stress and glycation, and inhibits inflammation through NF-κB and SASP. A standardized extract of Scutellaria baicalensis root reduces stress-induced senescence and harmful SASP, offering global anti-aging benefits by preventing and treating cellular senescence, promoting skin cell longevity and tissue health.​​​​​​​

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BIOGRAPHY
Born in the Principality of Monaco in 1982, Emmanuel Coste studied biology at Nice University (France) where he graduated in 2004. He moved to Paris and Montreal where he got his Master degree in multifactorial genetics at Pierre & Marie Curie University (Paris, France). He then studied cell biology at Edinburgh University (Scotland, UK) where he got his PhD in 2010 thanks to his work on the development of a novel treatment for rheumatoid arthritis. He joined EXSYMOL in 2011, as technical sales representative, and becomes Scientific Marketing Manager in 2020 where he uses his scientific and technical expertise to promote their innovative cosmetic actives worldwide.